AUTHOR=Li Pengyu , Chen Xianmeng , Chen Wanling , Huang Yunchao , Tan Xiangxiu , Chen Ying TITLE=Airway leech infestation masquerading as a tumor: a rare case report JOURNAL=Frontiers in Oncology VOLUME=Volume 15 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1572523 DOI=10.3389/fonc.2025.1572523 ISSN=2234-943X ABSTRACT=Airway obstruction is a ventilatory dysfunction caused by internal and external diseases of the respiratory tract, which is usually considered a life-threatening clinical emergency. Traditionally, airway obstruction can be caused by respiratory tumors, trauma, and foreign bodies, among which tumors are the most common. Consequently, physicians may prioritize tumor-related diagnoses, potentially leading to the misdiagnosis of rare non-neoplastic conditions. Here, we report a case of a 61-year-old adult traveler who initially presented with mild dyspnea and a bronchial space-occupying lesion on a CT scan, raising suspicion of an airway tumor. However, further examination confirmed the diagnosis of a living leech infestation in the bronchus, resulting from a trip to Laos. This case highlights the importance of thorough history-taking and critical thinking in clinical diagnosis, urging physicians to avoid overreliance on intuition or experience alone.