AUTHOR=Zhang Xiqiang , Jing Zhaoyi , Wu Longchao , Tao Ze , Lu Dandan 

TITLE=A predictive model to identify optimal candidates for surgery among patients with metastatic colorectal cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1573431

DOI=10.3389/fonc.2025.1573431

ISSN=2234-943X

ABSTRACT=PurposeTo improve clinical decision-making, we developed a predictive model to identify metastatic colorectal cancer (mCRC) patients who might benefit from primary tumor resection (PTR).Patients and MethodsWe extracted clinical data of stage IV CRC patients between 2010 and 2019 from the Surveillance, Epidemiology, and End Results database. Propensity score matching (PSM) was used to balance confounding factors by categorizing patients into surgery and non-surgery groups. To identify independent predictors of cancer-specific survival (CSS), we used multivariate Cox regression analysis. We further sorted patients who underwent surgery into benefit and non-benefit groups based on the median CSS of the non-surgery group; subsequently, we split the groups into training and test sets at a ratio of 6:4. To construct predictive models, we used the Boruta selection method to further filter variables, focusing on whether patients benefited from the surgery, based on key predictive factors.ResultsWe identified 23,649 mCRC patients, of whom 80.97% (19,148) underwent PTR. After PSM, compared to no surgical intervention, surgical intervention was independently associated with an extended median CSS [median: 22 vs. 12 months; HR: 2.323, P < 0.001]. Among the nine machine learning models, the Categorical Boosting model performed the best but was still slightly inferior to traditional logistic regression. The traditional logistic regression model showed good discriminative ability in both the training (area under the curve [AUC]: 0.727 [0.699-0.756]) and test (AUC: 0.741 [0.706-0.776]) sets.ConclusionWe achieved a predictive model which could identify optimal candidates for PTR among mCRC patients with high accuracy.