AUTHOR=Shi Yuhui , Liu Xianguo 

TITLE=Machine learning for prognostic impact in elderly unresectable hepatocellular carcinoma undergoing radiotherapy

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1585125

DOI=10.3389/fonc.2025.1585125

ISSN=2234-943X

ABSTRACT=Background/AimThis study develops a machine learning-based predictive model to evaluate the survival outcomes of elderly patients with unresectable hepatocellular carcinoma (HCC) undergoing radiotherapy.MethodsThe 2377 patients from SEER database were divided into training and internal validation cohorts. Additionally, 99 patients from our hospital were used for an external validation cohort. In the training cohort, 101 machine learning-based radiomics models were developed, and the optimal model’s performance was subsequently evaluated in both the internal and external validation cohorts.ResultsThe StepCox + GBM model demonstrated the highest C-index of 0.7 in the training cohort. The model was further evaluated using area under the receiver operating characteristic (AUC-ROC) curves, with AUC values ranging from 0.736 to 0.783, indicating strong predictive performance. Furthermore, the calibration curve and decision curves confirmed that the model had good predictive performance.ConclusionsThe StepCox + GBM model could help optimize the use of radiotherapy for elderly HCC patients, improving survival outcomes and guiding personalized treatment strategies.