AUTHOR=Troullioud Lucas Alexandre G. , Fiala Elise , Razeq Ahmed , Sauerhaft Talia , Price Anita P. , Mosquera Juan Miguel , Miyauchi Jeremy , Gao Ming , Walsh Michael F. , Ortiz Michael V. 

TITLE=Case Report: First report of a Wilms tumor in an individual with Dias–Logan syndrome (BCL11A-related intellectual disability)

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1585492

DOI=10.3389/fonc.2025.1585492

ISSN=2234-943X

ABSTRACT=Dias–Logan syndrome (DLS) is a rare condition caused by heterozygous germline BCL11A pathogenic variants associated with global developmental delay, distinctive facial features, and asymptomatic persistence of fetal hemoglobin. There has been no evidence of an association between DLS and increased risk of cancer. We report the first instance of a child with DLS diagnosed with cancer, a Wilms tumor (WT), who is notably much older than the typical onset. Although this case alone is insufficient to warrant routine WT screening in DLS, given the extreme rarity, we cannot rule out an association with DLS and WT predisposition.