AUTHOR=Song Yunrui , Wang Yuwei , Yang Mengqi , Yu Xinhao , Li Mengze , Long Bin , Shu Xiaolei , Zhang Xin , Wang Feng , Wang Chencheng , Hu Mengyu , Sui Jiang-Dong , Wang Ying 

TITLE=Individualization of clinical target volume delineation in eccentric nasopharyngeal carcinoma: a prospective comparative study

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1587764

DOI=10.3389/fonc.2025.1587764

ISSN=2234-943X

ABSTRACT=BackgroundClinical target volume (CTV) delineation is a major focus in radiotherapy for nasopharyngeal carcinoma (NPC) and currently lacks a universally accepted standard across treatment centers. We proposed an individualized CTV delineation method for eccentric NPC and evaluated its feasibility based on the eccentric distance of the primary lesion.Materials and methodsNinety patients with eccentric NPC were included. Each treatment plan was replanned using the individualized CTV method for dosimetric comparison with the conventional CTV, to evaluate coverage, homogeneity, and conformity of CTV and PTV, sparing of organs at risk (OARs) and radiotherapy technique. Paired sample t-tests and nonparametric rank-sum tests were used to compare target coverage, homogeneity, conformity, and OAR dose parameters between the two approaches. Correlation analysis is used to evaluate the correlation between eccentric distance of primary lesion and OARs dose changes. Subgroup analysis is used to compare the PTV and OARs dose parameters of individualized CTV at different T stages or radiotherapy techniques.ResultsOur results showed that compared with conventional CTV, the volume of CTV decreased significantly (P< 0.05) through individualizing delineation for eccentric NPC, especially CTV1 volume (95.81 cm³ vs. 57.57 cm³, P < 0.001). Individualized CTV reduced the doses delivered to OARs, including the brainstem, spinal cord, optic chiasm, optic nerves, and contralateral temporal lobe, inner ear and so on (all P< 0.05). When the eccentric distance of the primary lesion was between 1.4 and 2.1 cm, the individualized CTV approach provided significant advantages in organ protection, such as contralateral optic nerve, temporal lobe and parotid gland. Additionally, Subgroup analysis showed that the dose-sparing benefit of individualized CTV was more pronounced in patients treated with VMAT (volumetric modulated arc therapy).ConclusionThis study demonstrates the dosimetric advantages of individualized CTV delineation based on eccentric distance. Our prospective trial is currently ongoing for further research (NCT06167109).