AUTHOR=Wei Jiyong , Lan Yanni , Lan Guipeng , Gu Ronghe 

TITLE=A bibliometric analysis of liver cancer bone metastases: advances in mechanisms of occurrence and treatment options

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1594848

DOI=10.3389/fonc.2025.1594848

ISSN=2234-943X

ABSTRACT=BackgroundLiver cancer ranks as the sixth most frequently diagnosed cancer and is the third leading cause of cancer-related deaths worldwide. Its poor prognosis is mainly due to tumor metastasis. Bone metastasis commonly occurs in the advanced stages of liver cancer and can significantly impact patients’ quality of life and prognosis. However, current treatment methods for bone metastasis resulting from liver cancer have significant limitations. This article aims to review the latest research and trends in global studies on bone metastasis associated with liver cancer.MethodsThis study used the Web of Science Core Collection to gather 3,347 articles on liver cancer with bone metastasis published from 2004 to 2024.The study applied bibliometric analysis methods, including CiteSpace, VOSviewer, and other tools, to examine countries, institutions, journal authors, keywords, and references.ResultsFrom 2004 to 2024, we collected 3,845 records, including 3,347 articles and 498 reviews from 92 countries. Publications had shown exponential growth, peaking in 2021 with an annual growth rate of 8.3%. The research involved 13,188 organizations. China had the most publications (n=970, 29%), followed by the United States (n=648, 19.4%), Japan (n=317, 9.5%), and Germany (n=228, 6.8%); Canada had a notably higher rate of international collaboration at 44.8%. In total, 830 journals contributed to this research. The most cited journal was “J Clinical Oncol” with 4,275 citations, while “New Engl J Med” had the highest impact factor at 158.5. The research involved 23,710 authors, with Wang, Xin and Zhang, Chao being the authors with the most publications. Wang Z published the first study on this topic in 2007. In 2008, Zhang Y, Wang Y, and Zhang J also began researching this area and have continued to be actively involved since then. The study referenced a total of 79,935 sources, with the paper by Sung H et al., published in CA Cancer J Clin in 2021, achieving the highest citation rate of 42.46.ConclusionThis study systematically summarizes research findings on liver cancer with bone metastasis from 2004 to 2024, It also identifies and predicts global research hotspots and trends. In the future, the molecular mechanisms of liver cancer with bone metastasis will be a major research topic. The expansion of surgical treatment options and the advancement of innovative therapies will benefit more patients.