AUTHOR=Patrzałek Patryk , Froń Anita , Mielczarek Maja , Karwacki Jakub , Lesiuk Grzegorz , Janczak Dawid , Nagi Krystian , Krajewski Wojciech , Dębiński Paweł , Szydełko Tomasz , Małkiewicz Bartosz 

TITLE=Inflammatory-based prognostic indicators in prostate cancer: evaluating NLR, PLR, and SII in relation to Cambridge and ISUP classifications

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1595000

DOI=10.3389/fonc.2025.1595000

ISSN=2234-943X

ABSTRACT=IntroductionSystemic inflammation is increasingly recognized for its role in cancer prognosis. Inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic inflammation index (SII) are emerging as relevant factors in oncology. This study evaluates their associations with established prognostic classifications in prostate cancer (PCa): the Cambridge Prognostic Groups (CPG) and the International Society of Urological Pathology (ISUP) grading system.MethodsA retrospective cohort study was conducted on 272 prostate cancer patients using systematically collected clinical data. We calculated and analyzed NLR, PLR, and SII concerning CPG and ISUP scores.ResultsStatistically significant relationships were found between NLR, SII, and prognostic classifications. PLR did not demonstrate any significant association.ConclusionNLR and SII may be helpful to prognostic factors in PCa, particularly in outpatient settings. However, further multi-center validation and establishing standardized cut-off values are necessary.