AUTHOR=Çulha Merve , Lira Fabio S. , Rosa-Neto Jose C. 

TITLE=Molecular mechanism of aerobic exercise in miRNAs and the anti-tumoral effects

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1595982

DOI=10.3389/fonc.2025.1595982

ISSN=2234-943X

ABSTRACT=Exercise decreases cancer risk, prevents recurrence and enhances treatment efficacy, however its exact mechanisms remain unclear. This review aims to (i) summarize the miRNAs released during aerobic exercise and explore the factors influencing their levels; (ii) discuss the miRNAs associated with cancer and exercise. Exercise alters circulated-miRNA levels. Some of them show benefits on tumor and anti-tumoral immune cells (miRNA-1, miRNA-133, miRNA-206, miRNA-208, miRNA-486, miRNA-499) and others exert adverse effects (miRNA-21, miRNA-221). Mechanisms of exercise effects on cancer are complex due to some exercise- induced miRNAs exert advantageous, others not, individual characteristics and exercise features influencing the miRNAs levels. Further studies are needed to elaborate the exercise features on immune response and tumor cell functions, including miRNA production.