AUTHOR=Sun Leiyu , Zhou Yajuan , Yin Maoxu , Wang Fei , Yang Lijuan 

TITLE=Approaches to modeling cancer metastasis: from bench to bedside

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1602489

DOI=10.3389/fonc.2025.1602489

ISSN=2234-943X

ABSTRACT=Cancer metastasis modeling requires multidisciplinary approaches that integrate experimental, computational, and clinical research to unravel the complexities of cancer spread). By deepening our understanding of the metastatic process, researchers can efficiently and precisely develop targeted therapies and personalized treatment strategies to relieve the burden of metastasis on patients. In this review, we highlight the critical roles of experimental models in advancing knowledge of metastasis, identifying therapeutic targets, evaluating treatment strategies, and improving patient outcomes. These models serve as essential tools for translational research and drug discovery in the fight against metastatic cancer