AUTHOR=Hua Yunqi , Zhang Gangling , Liu Yubo , Tian Xiaoling , Zhang Xinyi , Song Ge , Tian Qinggang , Yin Fangrui 

TITLE=Regulation of sphingolipid metabolism in the immune microenvironment of gastric cancer: current insights and future directions

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1604227

DOI=10.3389/fonc.2025.1604227

ISSN=2234-943X

ABSTRACT=In recent years, the role of sphingolipid metabolism in the tumor immune microenvironment has gradually gained attention, particularly in gastric cancer research. Sphingolipids are crucial components of cell membranes that regulate cell signaling and immune responses, making them important in tumor biology research. Despite numerous studies exploring the relationship between sphingolipid metabolism and gastric cancer, the specific regulatory mechanisms remain unclear. Further investigation is needed to understand their roles in the immune microenvironment. This article aims to review the regulatory mechanisms of sphingolipid metabolism in the immune microenvironment of gastric cancer, discussing its potential applications in tumor occurrence, development, and treatment. By analyzing current research progress, we will clarify the complex relationship between sphingolipid metabolism and immune cell interactions and look forward to future research directions, hoping to provide new ideas and strategies for immunotherapy in gastric cancer.