AUTHOR=Nithagon Pichayut , Chahine Joeffrey , Stamatakis Lambros , Samdani Rashmi 

TITLE=Synchronous papillary renal neoplasm with reverse polarity and multilocular cystic renal neoplasm of low malignant potential in unilateral kidney: case report with molecular analysis and literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1605192

DOI=10.3389/fonc.2025.1605192

ISSN=2234-943X

ABSTRACT=Papillary Renal Neoplasm with Reverse Polarity (PRNRP) is a rare renal tumor, recently described in 2019 by Al-Obaidy et al. defined by characteristic histology of papillary neoplasm with apically located WHO/ISUP grade 1nuclei and frequent KRAS mutations. Multilocular cystic renal neoplasm of low malignant potential (MC-LMP) is an indolent tumor with a characteristic multicystic appearance with cysts lined by WHO/ISUP nuclear grade1 clear cells and presence of VHL alterations similar to that of clear cell renal cell carcinoma (ccRCC); therefore, considered its variant. Simultaneous occurrence of both these tumor types that are immunophenotypically and genetically distinct within same kidney is extremely rare and this is the first case report to date. Herein, we report a case of a 70-year-old male who was incidentally found to have bilateral renal cysts on imaging follow up for cardiovascular problems. The diagnosis of PRNRP and MC-LMP within the same kidney was made on histology in conjunction with ancillary tests. Awareness of PRNRP and MC-LMP is crucial for accurate diagnosis, as these tumors often resemble some of the aggressive variants of Renal cell carcinoma (RCC), such as Papillary RCC (pRCC) and ccRCC respectively on histology. Ability to correctly identify these indolent tumors is essential for optimal treatment options as they are often amenable to partial nephrectomy. This case underscores the need for further research into the pathogenesis and clinical implications of synchronous renal tumors with distinct immunophenotypes, and genomic profiles within the same kidney.