AUTHOR=Al-Kahtani Nouf , Jamjoom Mona M. , Khairi Ishak Mohamad , Mostafa Samih M. 

TITLE=Enhancing clinical diagnosis of laryngeal cancer through fusion-based transfer learning with Osprey Optimisation Algorithm using histology images

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1618349

DOI=10.3389/fonc.2025.1618349

ISSN=2234-943X

ABSTRACT=BackgroundLaryngeal squamous cell carcinoma is the most commonly diagnosed neck and head cancer. In contrast, the primary stage of pre-malignant and laryngeal cancer (LC) has to be handled with early diagnosis and treated with higher levels of laryngeal protection. Radiological evaluation with magnetic resonance imaging (MRI) and computed tomography (CT) techniques offers essential information on the disease in terms of the distance of the principal cancer and the existence of cervical lymph node metastasis. Recently, numerous deep learning (DL) and machine learning (ML) models have been implemented to classify the extracted features as either cancerous or healthy.MethodsIn this study, the Clinical Diagnosis of Laryngeal Cancer via Histology Images using the Fusion Transfer Learning and the Osprey Optimisation Algorithm (CDLCHI-FTLOOA) model is proposed. The aim is to improve the LC detection outcomes using histology image analysis to improve the patient’s life. Initially, the CDLCHI-FTLOOA model utilizes median filtering (MF)-based noise elimination during the image pre-processing process. Furthermore, the feature extraction process is performed by using the fusion models, namely AlexNet, SqueezNet, and CapsNet. The autoencoder (AE) method is employed for classification. To improve model performance, the Osprey Optimisation Algorithm (OOA) method is used for hyperparameter tuning to choose the optimal parameters for improved accuracy.ResultsTo exhibit the enhanced performance of the CDLCHI-FTLOOA model, a comprehensive experimental analysis is conducted under the laryngeal dataset. The comparison study of the CDLCHI-FTLOOA model portrayed a superior accuracy value of 97.16% over existing techniques.ConclusionTherefore, the proposed model can be employed for the accurate detection of the LC using the histopathological images.