AUTHOR=Li Chun-Sen , Zou Yun-Xuan , Wang Chun-Yan , Xu Guo-Dong , Yang Mai-Qing 

TITLE=Adenocarcinoma and squamous cell carcinoma in the same lobe of the lung with adenocarcinoma metastasis in the lymph nodes: a case report and literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1618619

DOI=10.3389/fonc.2025.1618619

ISSN=2234-943X

ABSTRACT=Adenocarcinoma and squamous cell carcinoma (SCC) of the same lobe of the lung is relatively rare. A 57-year-old man was admitted to Weifang People’s Hospital (Weifang, China) with blood streaks in sputum and had masses in the lung. Based on clinical, imaging, and pathological findings, the patient was diagnosed with primary adenocarcinoma and SCC in the same lobe of the right lung, with adenocarcinoma metastasis to the lymph nodes. Few reports have described the synchronous occurrence of adenocarcinoma and SCC in the same lobe. Thoracoscopic resection of the lower lobes of the right lung and mediastinal lymph node dissection were performed. Surgical resection and postoperative chemotherapy have superior effects. The misdiagnosis of this tumor as other types of tumor must be prevented. Immunohistochemical features can be useful for the diagnosis of primary adenocarcinoma and SCC.