AUTHOR=Xiong Hanchu , Li Rongxue , Yang Lixian , Li Yucheng , Ma Xiao 

TITLE=Dual regulation of the cGAS-STING pathway: new targets and challenges for subtype-specific immunotherapy in breast cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1619097

DOI=10.3389/fonc.2025.1619097

ISSN=2234-943X

ABSTRACT=Research on immune regulation mechanisms in breast cancer is crucial for breaking through therapeutic bottlenecks. This paper comprehensively reviews the dual roles of the cGAS-STING pathway in Luminal, HER2+, and triple-negative breast cancer (TNBC): its activation can enhance antitumor immunity, but chronic activation may lead to immunosuppression. By integrating molecular mechanisms, clinical translation, and subtype-specific strategies, it provides new directions for precision immunotherapy.