AUTHOR=Huang Hui-Yi , Liu Jia-Qi , Zeng Yun-Yun , Huang Zhi-Hao , Su Shan 

TITLE=Successful rescue of PD-1 inhibitor-induced TEN by vincristine combination therapy: a case report and literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1621494

DOI=10.3389/fonc.2025.1621494

ISSN=2234-943X

ABSTRACT=With the growing use of immune checkpoint inhibitors (ICIs) in the management of various solid malignancies, immune-related adverse events (irAEs) are increasingly recognized. Toxic epidermal necrolysis (TEN), though rare, represents a severe and potentially fatal cutaneous irAE with a high mortality rate. Owing to its low incidence and limited clinical data, a standardized treatment approach for ICI-induced TEN has not been established. We present a patient who developed TEN following the administration of a programmed cell death-1 inhibitor. The patient was successfully managed with a combination of vincristine, intravenous immunoglobulin, and glucocorticoids at the Department of Oncology, Guangzhou Chest Hospital.