AUTHOR=Lu Guoxiu , Tian Ronghui , Yang Wei , Zhao Jiayi , Chen Wenjing , Xiang Zijie , Hao Shanhu , Zhang Guoxu 

TITLE=Prediction of bone oligometastases in breast cancer using models based on deep learning radiomics of PET/CT imaging

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1621677

DOI=10.3389/fonc.2025.1621677

ISSN=2234-943X

ABSTRACT=ObjectiveTo develop a deep learning radiomics(DLR)model integrating PET/CT radiomics, deep learning features, and clinical parameters for early prediction of bone oligometastases (≤5 lesions) in breast cancer.MethodsWe retrospectively analyzed 207 breast cancer patients with 312 bone lesions, comprising 107 benign and 205 malignant lesions, including 89 lesions with confirmed bone metastases. Radiomic features were extracted from computed tomography (CT), positron emission tomography (PET), and fused PET/CT images using PyRadiomics embedded in the uAI Research Portal. Standardized feature extraction and feature selection were performed using the Least Absolute Shrinkage and Selection Operator (LASSO) method. We developed and validated three models: a radiomics-based model, a deep learning model using BasicNet, and a deep learning radiomics (DLR) model incorporating clinical and metabolic parameters. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity. Statistical comparisons were conducted using the DeLong test.ResultsVisual assessment of fused PET/CT images identified 227 (72.8%) abnormal lesions, demonstrating greater sensitivity than CT or PET alone. The complex radiomics model achieved a sensitivity of 98.9% [96.1%–99.4%], specificity of 98.2% [88.1%–99.6%], accuracy of 98.7% [89.6%–99.5%], and area under the curve (AUC) of 0.989. The BasicNet model outperformed other transfer learning models, achieving an AUC of 0.961. The DeLong test confirmed that the AUC of the BasicNet model was significantly higher than the traditional radiomics model. The DLR+Complex model with a random forest classifier achieved the highest overall performance, with an AUC of 0.990, sensitivity of 98.6%, specificity of 90.5%, and accuracy of 99.8%.ConclusionsThe BasicNet model significantly outperformed traditional radiomics approaches in predicting bone oligometastases in breast cancer patients. The DLR+Complex model demonstrated the best predictive performance across all metrics. Future strategies for precise diagnosis and treatment should incorporate histologic subtype, advanced imaging, and molecular biomarkers.