AUTHOR=Qin Xianfei , Shi Jinping , Zhao Xiangkun , Zhang Yu , Liu Xueyan , Wang Li 

TITLE=Identifying sinonasal inverted papilloma by machine learning: a systematic review and meta-analysis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1628999

DOI=10.3389/fonc.2025.1628999

ISSN=2234-943X

ABSTRACT=BackgroundSinonasal inverted papilloma (IP) is a benign tumor of the sinonasal mucosa, which may become malignant. Machine learning (ML) has been applied to improve the accuracy in the diagnosis of various diseases, but no studies have evaluated the performance of ML for IP diagnosis. This systematic review and meta-analysis aimed to explore the diagnostic performance of ML for IP.MethodsWe systematically searched articles from PubMed, Cochrane, Embase, and Web of Science up to July 22, 2025. The quality assessment of diagnostic accuracy studies tool (QUADAS-2) was used to assess the risk of bias, and the bivariate mixed-effect model was used for meta-analysis.Results17 studies involving 3321 participants were included. In the validation set, the sensitivity and specificity of ML constructed based on radiomics for identifying IP and malignant tumors were 0.84 (95%CI: 0.77-0.89) and 0.82 (95% CI: 0.74 ~ 0.88), respectively. The sensitivity and specificity of ML constructed based on radiomics and clinical features for identifying IP and malignant tumors were 0.85 (95%CI: 0.78-0.90) and 0.87 (95% CI: 0.80 ~ 0.92), respectively.ConclusionOur study shows that ML has a favorable performance in the differential diagnosis of IP. More prospective studies are needed to validate and develop universal tools.Systemic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/view/CRD42023430417, identifier CRD42023430417.