AUTHOR=Zhu Shaopeng , Zou Yunpeng , Guo Jie , Ma Wenqi , Lu Laitong , Liu Ronghan , Kang Jianning , Zhao Kai , Zhong Jiangbo 

TITLE=IQGAP1: cross-disease target via receptor-pathway networks

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1632060

DOI=10.3389/fonc.2025.1632060

ISSN=2234-943X

ABSTRACT=IQGAP1, a versatile scaffolding protein, critically regulates cytoskeletal organization, cell motility, proliferation, and signaling cascades. Beyond coordinating these cellular functions, it is increasingly recognized as a key driver in malignancies, immune dysfunction, metabolic dysregulation, and cardiovascular pathologies. By binding receptor tyrosine kinases, small GTPases, and downstream effectors, IQGAP1 modulates oncogenesis, immune evasion, and metabolic imbalance, while contributing to chemoresistance. This review synthesizes advances in IQGAP1’s structural domains, disease-specific signaling networks, and therapeutic targeting strategies, emphasizing its translational potential in developing precision therapies for cancer, metabolic syndromes, and immune disorders.