AUTHOR=Han Weijuan , Dong Xinjie , Wang Guixia , Ding Yuwen , Yang Aolin TITLE=Application and improvement of YOLO11 for brain tumor detection in medical images JOURNAL=Frontiers in Oncology VOLUME=Volume 15 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1643208 DOI=10.3389/fonc.2025.1643208 ISSN=2234-943X ABSTRACT=Brain tumors pose a critical threat to human health, and early detection is essential for improving patient outcomes. This study presents two key enhancements to the YOLOv11 architecture aimed at improving brain tumor detection from MRI images. First, we integrated a set of novel attention modules (Shuffle3D and Dual-channel attention) into the network to enhance its feature extraction capability. Second, we modified the loss function by combining the Complete Intersection over Union (CIoU) with a Hook function (HKCIoU). Experiments conducted on a public Kaggle dataset demonstrated that our improved model reduced parameters and computations by 2.7% and 7.8%, respectively, while achieving mAP50 and mAP50–95 improvements of 1.0% and 1.4%, respectively, over the baseline. Comparative analysis with existing models validated the robustness and accuracy of our approach.