AUTHOR=Li Yuping , Feng Bao , Chen Yuan , Ruan Xiaohong , Shi Jiangfeng , Wang Ximiao , Wen Xianyan , Li Peijun , Sun Junqi , Zheng Changye , Zou Yujian , Li Mingwei , Long Wansheng , Chen Yehang , Xie Dong 

TITLE=FedCMC: a federated learning model with contribution fairness based on multi-center core data extraction for assessing the myometrial invasion status of endometrial cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1648502

DOI=10.3389/fonc.2025.1648502

ISSN=2234-943X

ABSTRACT=BackgroundMulti-center Federated Learning (FL) has played a significant role in disease prediction, offering a feasible solution to the challenges of cross-institutional collaboration. However, the fairness issues inherent in traditional FL frameworks have limited their further development in the medical field.MethodsWe propose a Contribution Fairness Federated Learning model based on Multi-center Core Data Extraction (FedCMC). This model accurately assesses the actual contributions of each center from both data and model perspectives using two fairness indicators: data information richness and model quality. In the data contribution assessment phase, we innovatively design a Multi-center Core Data Extraction Module (MCDEM). This module extracts representative core datasets from the original training pool, effectively filtering redundant information and enhancing the fairness of data contribution assessment and the model's generalization ability. Subsequently, weighted aggregation based on each center's contribution optimizes the benefits for high-contribution centers, incentivizing more users to participate in federated learning. Finally, a personalized federated learning strategy is adopted, enabling the model to fine-tune through each center's core dataset, thereby improving its prediction relevance and accuracy.ResultsWe analyze data from 902 endometrial cancer (EC) patients across four independent medical institutions. In centers A, B, and C, the FedCMC model achieves areas under the ROC curve (AUC) of 0.8261, 0.8750, and 0.8964, respectively. Comparative analysis with three traditional federated learning algorithms indicates that FedCMC offers significant advantages in both performance and fairness.ConclusionFedCMC effectively alleviates fairness issues in traditional FL frameworks and accurately predicts the myometrial invasion (MI) status of EC patients, supporting personalized treatment strategies.