AUTHOR=Polaniak Renata , Kwiatkowski Aleksander , Górski Michał , Grochowska-Niedworok Elżbieta , Latocha Małgorzata 

TITLE=The role of cytostatic in oxidative stress reactions

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1667522

DOI=10.3389/fonc.2025.1667522

ISSN=2234-943X

ABSTRACT=Cytostatic drugs are widely applied in cancer therapy. Among the most commonly used agents are anthracyclines, such as doxorubicin, and platinum (II) complexes, including cisplatin, carboplatin, and oxaliplatin. Treatment with cytostatic drugs has been shown to enhance the mitochondrial production of reactive oxygen species (ROS). Cells regulate redox homeostasis through scavenging systems, with antioxidant enzymes playing a crucial role in neutralizing ROS. Key enzymes involved in this defense include superoxide dismutase, catalase, and glutathione S-transferase, whose activity may be modulated under oxidative stress conditions. Previous research has documented the effects of cytostatic drugs on cancer cell cultures in vitro, as well as the corresponding alterations in antioxidant enzyme activity observed under these conditions.