AUTHOR=Talarico Marco , Vischini Gisella , Barbato Simona , Restuccia Roberta , Masci Simone , Sacchetti Ilaria , Manzato Enrica , Ghibellini Stefano , Puppi Michele , Iezza Miriam , Rizzello Ilaria , Pantani Lucia , Tacchetti Paola , Borsi Enrica , Solli Vincenza , Terragna Carolina , Agostinelli Claudio , La Manna Gaetano , Cavo Michele , Zamagni Elena , Mancuso Katia 

TITLE=Case Report: Uncommon co-occurrence of different renal histopathological entities in a patient with multiple myeloma and lymphoplasmacytic lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1672690

DOI=10.3389/fonc.2025.1672690

ISSN=2234-943X

ABSTRACT=In patients with plasma cell dyscrasias presenting with kidney injury, renal biopsy usually displays the presence of a single histological damage. However, the coexistence of heterogeneous damages has been occasionally described and is associated with worse renal outcomes. In this report, we describe the case of a patient with a concomitant diagnosis of multiple myeloma and lymphoplasmacytic lymphoma, presenting with acute kidney injury and with renal biopsy revealing the unexpected concurrent presence of several different renal damages, who achieved a good hematologic response and dialysis independence after anti-myeloma therapy.