AUTHOR=Pan Wenjie , Wang Liangliang , Wei Miaomiao , Wu Xiangkui , Li Hai , Wu Bihua , Xiao Shune , Deng Chengliang 

TITLE=Skin-derived vascularized lymph node transfer combining with liposuction in stages for bilateral lower extremity lymphedema: a case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1677136

DOI=10.3389/fonc.2025.1677136

ISSN=2234-943X

ABSTRACT=Bilateral lower extremity lymphedema (LEL) significantly impairs patients’ quality of life. A 66-year-old female patient, who developed bilateral LEL following cervical cancer surgery (classified as International Society of Lymphology stage II), presented to our hospital. In a two-stage surgical approach, we employed two distinct lymph node transfer techniques: (1) transplantation of a 7 × 2 cm vascularized lymph node flap harvested from the right supraclavicular region to the left popliteal fossa, and (2) transplantation of a 9 × 3 cm skin-derived lymph node flap obtained from the submental area to the right popliteal fossa. Both procedures were combined with liposuction. Postoperative management included compression therapy, with no complications observed during the recovery period. The patient demonstrated significant improvement in quality-of-life measures. Lymphoscintigraphic imaging at the 12-month follow-up revealed improvement in lymphatic function, showing volume reductions of 2129.28 mL (left lower limb) and 1699.65 mL (right lower limb). No recurrence of swelling was reported during the 30-month follow-up period. This case suggests that a two-stage approach combining vascularized lymph node transfer (VLNT) with liposuction may represent an effective treatment strategy for bilateral lower extremity lymphedema.