Frontiers in Oncology

Case Report

Published on 11 Dec 2025

Case Report: S100-negative primary anorectal melanoma with elevated Ki67: a case for biology-driven radical resection despite early radiological staging

in Surgical Oncology

Xiangxiang Ren
Tianhao Xie
Litao Liu
Xiaoshi Jin
Wei Ma
Jing Sun
Meng Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1682861

408 views

Systematic Review

Published on 11 Dec 2025

Prognostic value of platelet to lymphocyte ratio in patients with castration-resistant prostate cancer: a systematic review and meta-analysis

in Genitourinary Oncology

Junhui Ying
Changchun Zhou
Yili Jin

Frontiers in Oncology

doi 10.3389/fonc.2025.1655520

181 views

Case Report

Published on 11 Dec 2025

Malignant phyllodes tumor of the breast with short-term multiple recurrences and systemic distant metastasis: a case report and literature review

in Breast Cancer

Min Zhang
Lisha Zhou
Xudong Gao
Mengfan Zhao
Rupei Ye
Bin Liang
Bin Wu

Frontiers in Oncology

doi 10.3389/fonc.2025.1715674

332 views

Original Research

Published on 11 Dec 2025

Mechanism of action of Butein in cutaneous squamous cell carcinoma through regulation of the TWEAK-FN14 signaling pathway

in Skin Cancer

Qinyi Dong
Zijian Zhang
Siying Li
Xinman Wang
Han Zhang
Jiahao Bai
Kaili Zheng
Lili Liang

Frontiers in Oncology

doi 10.3389/fonc.2025.1725848

605 views

Original Research

Published on 11 Dec 2025

EMP1 regulates cell proliferation, migration and invasion in triple negative breast cancer through PI3K‐AKT signaling

in Breast Cancer

Zheng Shu
Yonghao Li
Benshuo Zhu
Qinglin Zhou
Nuofan Li
Zike Shan
Mei Zhang

Frontiers in Oncology

doi 10.3389/fonc.2025.1701470

524 views

Systematic Review

Published on 11 Dec 2025

Effects of race and ethnicity on hematopoietic stem cell transplant outcomes in acute myeloid leukemia: a systematic review and meta-analysis

in Hematologic Malignancies

Ana Melo
Shakeel Ahmed
Masuma Anzuman
Siaana Allana
Michelle Kilcoyne
Vutha Nhim
Osvaldo Padilla
Alok K. Dwivedi
Anna M. Eiring

Frontiers in Oncology

doi 10.3389/fonc.2025.1703050

544 views

Systematic Review

Published on 11 Dec 2025

Efficacy of TACE plus tyrosine kinase inhibitors and immune checkpoint inhibitors in patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis

in Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers

Kailin Ye
Jiale Zhou
Jie Lin
Yongzhi Li
Yansong Luo
Fei Xie

Frontiers in Oncology

doi 10.3389/fonc.2025.1707622

324 views

Case Report

Published on 11 Dec 2025

Case report: Preliminary experience with organ-preserving treatment for locally advanced esophageal cancer in the immunotherapy era: a case series of four patients

in Gastrointestinal Cancers: Gastric and Esophageal Cancers

Genrong Yang
Han Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1700288

326 views

Case Report

Published on 11 Dec 2025

Unusual localization of pilocytic astrocytoma at the foramen of Monro mimicking a colloid cyst: a case report and literature review

in Neuro-Oncology and Neurosurgical Oncology

Arturs Balodis
Sigita Zalite
Inese Briede
Jurijs Nazarovs
Liga Jaunozolina
Evija Bergfelde
Tõnu Rätsep
Kaspars Auslands

Frontiers in Oncology

doi 10.3389/fonc.2025.1717175

498 views

Original Research

Published on 11 Dec 2025

Leucine-rich repeat neuronal 1 as a prognostic indicator and functional modulator in breast cancer

in Breast Cancer

Jiaxin Wang
Xiqian Zhou
Ding Ping
Meiling Lu
Yue Zhang
Hongming Song
Junyong Zhao
Dengfeng Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1724785

395 views

Original Research

Published on 11 Dec 2025

Proton-boron capture interaction enhances killing of radiation resistant cancer cells

in Radiation Oncology

Dalong Pang
Mira Jung
Alfredo Velena
William Parke
Anatoly Dritschilo

Frontiers in Oncology

doi 10.3389/fonc.2025.1720143

292 views

Review

Published on 11 Dec 2025

Overcoming the sorafenib resistance mechanism in FLT3-mutated acute myeloid leukemia: molecular basis and new targets

in Cancer Molecular Targets and Therapeutics

Hui Peng
Min Li
Yuan Yuan Peng
Xiao Lan Li
Jing Yang
Qiang Ge Sun
Kui Song

Frontiers in Oncology

doi 10.3389/fonc.2025.1713174

426 views

Original Research

Published on 11 Dec 2025

A CT-based interpretable machine learning model for preoperative prediction of pancreatic neuroendocrine tumor aggressiveness

in Gastrointestinal Cancers: Hepato Pancreatic Biliary Cancers

Rong Kong
Shunzu Lu
Yugui Huang
Siyu Tan
Chunxia Zhu
Guowei Chen
Mingrui Yang
Ying Liu
Qixin Wu
Peng Peng

Frontiers in Oncology

doi 10.3389/fonc.2025.1665601

284 views

Editorial

Published on 11 Dec 2025

Editorial: Metabolic crosstalk between cancer cells and immune cells in the tumor microenvironment: cellular and molecular insights, and their therapeutic implications

in Cancer Metabolism

Parmanand Malvi
Shivendra Vikram Singh
Balkrishna Chaube

Frontiers in Oncology

doi 10.3389/fonc.2025.1751044

234 views

Original Research

Published on 11 Dec 2025

Higher diversity and abundance of microRNA-455-5p isoforms confer suppressive role in Wilms’ tumor

in Pediatric Oncology

Cao Chen
Zhou Zhou
Chunfang Yao
Xiaowei Li
Yifei Wang
Xiaogang Zhou
Hengli Ni

Frontiers in Oncology

doi 10.3389/fonc.2025.1681367

328 views

Original Research

Published on 11 Dec 2025

Are we overestimating proton minibeam therapy effectiveness through physical dose metrics?

in Radiation Oncology

Kaan Dere
Ahmet Cemal Usta
Reyhan Serra Kurnaz
Liyong Lin
Yong Yang
Murat Surucu
Serdar Charyyev

Frontiers in Oncology

doi 10.3389/fonc.2025.1682511

738 views

Original Research

Published on 11 Dec 2025

Efficacy and safety of high-intensity focused ultrasound ablation under general anesthesia in older hepatocellular carcinoma patients

in Cancer Imaging and Image-directed Interventions

Siyu Xie
Lifeng Ran
Wei Yang
Kun Zhou
Chengbing Jin
Hui Zhu

Frontiers in Oncology

doi 10.3389/fonc.2025.1702332

327 views

Original Research

Published on 11 Dec 2025

Benchmarking GPT-5 in radiation oncology: measurable gains, but persistent need for expert oversight

in Radiation Oncology

Udo S. Dinc
Jibak Sarkar
Philipp Schubert
Sabine Semrau
Thomas Weissmann
Andre Karius
Johann Brand
Bernd-Niklas Axer
Ahmed Gomaa
Pluvio Stephan

Frontiers in Oncology

doi 10.3389/fonc.2025.1695468

469 views

Original Research

Published on 11 Dec 2025

Toxicity profiles of cyclin-dependent kinase 4/6 inhibitors: safety analysis from clinical trials and the FDA adverse event reporting system

in Breast Cancer

Jin Zhou
Xinmiao Lin
Shue Wang
Mumu Xie
Xiao Hu
Jiaqin Cai

Frontiers in Oncology

doi 10.3389/fonc.2025.1673284

387 views

Original Research

Published on 11 Dec 2025

Effect of early detubularization on urethro-intestinal anastomosis during robot-assisted radical cystectomy and intracorporeal neobladder among bladder cancer patients

in Genitourinary Oncology

Jong Ho Park
Hakmin Lee
Sangchul Lee
Sung Kyu Hong
Seok-Soo Byun
Jong Jin Oh

Frontiers in Oncology

doi 10.3389/fonc.2025.1680595

418 views

Systematic Review

Published on 11 Dec 2025

Cerebrospinal fluid ctDNA as a diagnostic and prognostic tool in gliomas: a systematic review and meta-analysis

in Neuro-Oncology and Neurosurgical Oncology

Rebeca Pérez-Alfayate
Mateo Paz-Cabezas
Pedro Pérez-Segura
Rafael Sanchez del Hoyo
Santiago Cabezas-Camarero

Frontiers in Oncology

doi 10.3389/fonc.2025.1714287

372 views

Case Report

Accepted on 10 Dec 2025

Comprehensive management of chest wall recurrent HER2-positive breast cancer with Anlotinib and hypofractionated radiotherapy:A Case Report

in Radiation Oncology

Jing Xu
Qing Liu
Yue Yin
Guanglu Dong

Frontiers in Oncology

178 views

Case Report

Accepted on 10 Dec 2025

Case Report: A Rare Case of Synchronous Ovarian Mixed Germ Cell Tumor and Mast Cell Leukemia in a Pediatric Patient

in Pediatric Oncology

Chengzhu Liu
Jinhua Chu
Yang Wan
Huiping Wang
Hongzhen Yu
Kunlong Zhang
Zhiwei Xie
Songji Tu
Ningling Wang
Linhai Yang

Frontiers in Oncology

105 views

Original Research

Accepted on 10 Dec 2025

Pencil beam scanning proton lattice radiotherapy: single-field versus multi-field optimization

in Radiation Oncology

Shouyi Wei
Lee Xu
Hang Qi
Ajay Zheng
Milo Vermeulen
Annemarie Shepherd
Kaled Alektiar
Nancy Y Lee
Richard Bakst
Chandan Guha

Frontiers in Oncology

34,155 articles

articles

Case Report: S100-negative primary anorectal melanoma with elevated Ki67: a case for biology-driven radical resection despite early radiological staging

Prognostic value of platelet to lymphocyte ratio in patients with castration-resistant prostate cancer: a systematic review and meta-analysis

Malignant phyllodes tumor of the breast with short-term multiple recurrences and systemic distant metastasis: a case report and literature review

Mechanism of action of Butein in cutaneous squamous cell carcinoma through regulation of the TWEAK-FN14 signaling pathway

EMP1 regulates cell proliferation, migration and invasion in triple negative breast cancer through PI3K‐AKT signaling

Effects of race and ethnicity on hematopoietic stem cell transplant outcomes in acute myeloid leukemia: a systematic review and meta-analysis

Efficacy of TACE plus tyrosine kinase inhibitors and immune checkpoint inhibitors in patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis

Case report: Preliminary experience with organ-preserving treatment for locally advanced esophageal cancer in the immunotherapy era: a case series of four patients

Unusual localization of pilocytic astrocytoma at the foramen of Monro mimicking a colloid cyst: a case report and literature review

Leucine-rich repeat neuronal 1 as a prognostic indicator and functional modulator in breast cancer

Proton-boron capture interaction enhances killing of radiation resistant cancer cells

Overcoming the sorafenib resistance mechanism in FLT3-mutated acute myeloid leukemia: molecular basis and new targets

A CT-based interpretable machine learning model for preoperative prediction of pancreatic neuroendocrine tumor aggressiveness

Editorial: Metabolic crosstalk between cancer cells and immune cells in the tumor microenvironment: cellular and molecular insights, and their therapeutic implications

Higher diversity and abundance of microRNA-455-5p isoforms confer suppressive role in Wilms’ tumor

Are we overestimating proton minibeam therapy effectiveness through physical dose metrics?

Efficacy and safety of high-intensity focused ultrasound ablation under general anesthesia in older hepatocellular carcinoma patients

Benchmarking GPT-5 in radiation oncology: measurable gains, but persistent need for expert oversight

Toxicity profiles of cyclin-dependent kinase 4/6 inhibitors: safety analysis from clinical trials and the FDA adverse event reporting system

Effect of early detubularization on urethro-intestinal anastomosis during robot-assisted radical cystectomy and intracorporeal neobladder among bladder cancer patients

Cerebrospinal fluid ctDNA as a diagnostic and prognostic tool in gliomas: a systematic review and meta-analysis

Comprehensive management of chest wall recurrent HER2-positive breast cancer with Anlotinib and hypofractionated radiotherapy:A Case Report

Case Report: A Rare Case of Synchronous Ovarian Mixed Germ Cell Tumor and Mast Cell Leukemia in a Pediatric Patient

Pencil beam scanning proton lattice radiotherapy: single-field versus multi-field optimization