AUTHOR=Lent-Schochet Daniella , Akbar Mizna , Hou Joshua H. , Farooq Asim V. 

TITLE=Diagnostic approach to limbal stem cell deficiency

JOURNAL=Frontiers in Ophthalmology

VOLUME=Volume 4 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/ophthalmology/articles/10.3389/fopht.2024.1524595

DOI=10.3389/fopht.2024.1524595

ISSN=2674-0826

ABSTRACT=Limbal stem cell deficiency (LSCD) is an important cause of visual and ocular morbidity. Effective diagnosis and management require a thoughtful and comprehensive evaluation of the ocular surface. This review describes the pathogenesis, diagnosis, and grading of LSCD, as well as characteristic findings via slit lamp examination, in-vivo confocal microscopy, anterior segment optical coherence tomography (AS-OCT), impression cytology, and OCT angiography.