AUTHOR=Vaillancourt Katy , Ben Lagha Amel , Grenier Daniel 

TITLE=Effects of a Berry Polyphenolic Fraction on the Pathogenic Properties of Porphyromonas gingivalis

JOURNAL=Frontiers in Oral Health

VOLUME=Volume 3 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2022.923663

DOI=10.3389/froh.2022.923663

ISSN=2673-4842

ABSTRACT=Porphyromonas gingivalis expresses a broad array of virulence factors that enable it to play a central role in the pathogenesis of the chronic form of periodontitis. The aim of the present study was to investigate the effects of a commercial berry polyphenolic fraction (Orophenol®) composed of wild blueberry, cranberry, and strawberry extracts on the main pathogenic properties of P. gingivalis. Orophenol® attenuated the growth of P. gingivalis and decreased its hemolytic activity, its adherence to a basement membrane matrix model, and its proteinase activities. The berry polyphenolic fraction also impaired P. gingivalis-induced reactive oxygen species (ROS) production by oral keratinocytes. Lastly, the fraction exerted a protective effect on the integrity of the oral keratinocyte barrier in an in vitro model infected with P. gingivalis. In conclusion, the berry polyphenolic fraction investigated in the present study attenuated several pathogenic properties of P. gingivalis. Although future clinical investigations are required, our study provided evidence that the polyphenols in this fraction may be promising bioactive molecules for preventing and/or treating periodontal disease.