AUTHOR=Jaber Mohamed , Ingafou Mohamed Saleh Hamad , Nireeksha  , Maniangat Luke Alexander 

TITLE=Exploring the association of calbindin –D28K in renal dialysis with oral health: a comprehensive review

JOURNAL=Frontiers in Oral Health

VOLUME=Volume 6 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2025.1523024

DOI=10.3389/froh.2025.1523024

ISSN=2673-4842

ABSTRACT=BackgroundThe kidney, brain, and endocrine glands all express calbindin-D28K, a calcium-binding protein that is essential for maintaining calcium homeostasis. Calcium metabolism is disturbed in chronic kidney disease (CKD), which may have an impact on dental and bone health. Patients on dialysis frequently have changed salivary composition, which raises their risk of dental problems such tooth decay and periodontal disease. Although there is no direct study on the relationship between Calbindin-D28K and dental health in dialysis patients, its function in calcium control raises the possibility of a connection that merits more investigation.ObjectiveTo address the impact of Calbindin-D28K levels in chronic kidney disease on oral health.DesignA comprehensive electronic search was conducted using databases like PubMed, ResearchGate, SCOPUS, and others, to find relevant articles published before May 2024. The search terms included Calbindin-D28K, renal dialysis, dental and oral health, Vitamin D, calcium, end-stage renal disease, and related topics. The review examined studies from 1975 to 2024, focusing on the relationship between dental health and renal dialysis and factors affecting Calbindin-D28K levels.ResultsA total of 48 articles were retrieved through electronic database. After evaluating the title, abstract, and full text of these articles, only 7 were selected for the present review. Final consideration: Based on the data available on selected studies, they point to a possible association between these people's higher frequency of periodontal disease and tooth caries and lower levels of Calbindin-D28K.It is imperative to recognize the reciprocal impact of systemic illnesses on oral health. In addition to being important for maintaining calcium homeostasis, calbindin-D28K may also be a biomarker for renal damage and have an impact on dental health. Its relevance for both diagnosis and treatment of chronic kidney disease and associated diseases is highlighted by its involvement in renal function and neuroprotection.