AUTHOR=Liu Wenjing , Xu Xuezhong , Wang Junqiang , Li Zhidan TITLE=Rescuing a “hopeless” tooth with severe internal resorption during orthodontic therapy: a case report JOURNAL=Frontiers in Oral Health VOLUME=Volume 6 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2025.1604976 DOI=10.3389/froh.2025.1604976 ISSN=2673-4842 ABSTRACT=Root resorption is one of the leading complications that follows orthodontic treatment. It's an inflammatory process involving ischemic necrosis. Therefore, it is called orthodontically induced inflammatory root resorption (OIIRR). The purpose of this report is to present a case study of a patient in her 20s who experienced internal root resorption on two maxillary central incisors as a result of orthodontic treatment. Mineral trioxide aggregates (MTAs) were applied to the root resorption lesion to promote remineralization. A clinical and radiographic examination revealed that no radiolucency related to the resorptive lesion was found without any pathological symptoms after a 3-year follow-up.