AUTHOR=Cavicchiolo Maria Elena , Daverio Marco , Battajon Nadia , Frigo Anna Chiara , Lago Paola 

TITLE=A Single Dose of Oral Sucrose Is Enough to Control Pain During Venipuncture: A Randomized Controlled Trial

JOURNAL=Frontiers in Pain Research

VOLUME=Volume 3 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2022.888076

DOI=10.3389/fpain.2022.888076

ISSN=2673-561X

ABSTRACT=Sucrose is effective in reducing pain during minor procedures in neonates. We evaluated whether a second dose of sucrose was more effective than a single dose during venipuncture. We performed a randomised, double-blind, controlled trial at the NICU of Padua Hospital(August 2016-October 2017). We randomised 72 preterm infants undergoing venipuncture for routine test to a control group, which received a single standard dose of sucrose 2' before the procedure and a placebo 30" after the venipuncture, and an experimental group in which they received two doses of 24% sucrose 2' before and 30" after the venipuncture. 
No difference in pain perception was found between the groups at 30", 60" and 120". In conclusion,we do not recommend a second dose of sucrose during venipuncture in prematures.