AUTHOR=Azam Muhammad Abid , Weinrib Aliza Z. , Slepian P. Maxwell , Rosenbloom Brittany N. , Waisman Anna , Clarke Hance , Katz Joel TITLE=Effects of perioperative clinical hypnosis on heart rate variability in patients undergoing oncologic surgery: secondary outcomes of a randomized controlled trial JOURNAL=Frontiers in Pain Research VOLUME=Volume 5 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2024.1354015 DOI=10.3389/fpain.2024.1354015 ISSN=2673-561X ABSTRACT=Clinical hypnosis has been proposed for post-surgical pain management for its potential vagal-mediated anti-inflammatory properties. Evidence is needed to understand its effectiveness for post-surgical recovery. Iin this secondary outcome study, it was hypothesized that surgical oncology patients randomized to receive perioperative clinical hypnosis (CH) would demonstrate greater heart-rate variability (HRV) during rest and relaxation at a 1-month post-surgery assessment compared to a treatment-as-usual group (TAU). After REB approval, trial registration and informed consent, 92 participants were randomized to receive CH (n=45) or TAU (n=47). CH participants received a CH session before surgery and during post-surgical inhospital stay HRV was assessed during rest (5 min) and relaxation (10 min) before and 1-month after surgery. Pain intensity was obtained using a 0-10 numeric rating scale pre and post 1-week and 1-month post surgery. One month after surgery, HRV was significantly higher in CH group (n = 29) during rest and relaxation (both p<0.05, d=0.73) than TAU group (n= 28). By contrast, rest and relaxation HRV decreased from pre-to 1-month post-surgery for the TAU (both p<0.001, d>0.48) but not the CH group. Pain intensity increased from pre-surgery to 1-week post-surgery (p<0.001, d=0.50), and decreased from 1-week to 1-month post-surgery (p=0.005, d=0.21) for all participants. The results suggest that hypnosis prevents the deleterious effects of surgery on HRV by preserving pre-operative vagal activity. These findings underscore the potential of clinical hypnosis in mitigating the adverse effects of surgery on autonomic function and may have significant implications for enhancing post-surgical recovery and pain management strategies.Trial registration: NCT00373050 at ClinicalTrials.gov.