AUTHOR=Sirufo Maria Maddalena , Ginaldi Lia , De Martinis Massimo 

TITLE=Successful Treatment With Omalizumab in a Child With Asthma and Urticaria: A Clinical Case Report

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 7 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2019.00213

DOI=10.3389/fped.2019.00213

ISSN=2296-2360

ABSTRACT=Urticaria of childood is rare and more uncommon is  its persistence.Comorbidities are associated with CSU in children, among these asthma, allergic rhinitis or atopic dermatitis, while many children with CSU have a family history of atopy.
Therapeutic approach to CSU in children is the same recommended in international guidelines for management of chronic urticaria in adults.
In the European Union, according to European Medicine Agency,  Omalizumab is indicated as add-on therapy for the treatment of chronic spontaneous urticaria in adult and adolescent (12 years and above) patients with inadequate response to H1 antihistamine treatment. Furthermore in children (6 to <12 years of age) is indicated as add-on therapy to improve asthma control.The treatment of children with urticaria under the age of 12 represents a therapeutic “limbo”, being possible to administer omalizumab only “off label”.