AUTHOR=Wang Huan , Wang Yuesheng , Wang Ruifeng , Li Xiaoqin 

TITLE=Case Report: Two Infant Cases of Langerhans Cell Histiocytosis Involving the Digestive Tract

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.545771

DOI=10.3389/fped.2021.545771

ISSN=2296-2360

ABSTRACT=Langerhans cell histiocytosis (LCH) is a rare disease with uncertain etiology. LCH with involvement of the gastrointestinal tract is rare and typically identified in pediatric patients with systemic disease. Here, we report 2 infantile cases of LCH who initially presented with diarrhea, hematochezia and rash and were histologically missed on original sections of a colonic biopsy.The diagnosis of LCH were verified later with immunohistochemistry examinations. Combining our experience and reports before, multi-hemorrhagic spots of the colorectal mucosa, as well as narrowness and erosion of the distal duodenum might be a suggestive manifestation of gastrointestinal involvement in LCH in the endoscopy tests, which might be helpful for the early recognition of the disease.