AUTHOR=Joshi Tejas P. , Anvari Sara , Gupta Meera R. , Davis Carla M. , Hajjar Joud 

TITLE=Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.646997

DOI=10.3389/fped.2021.646997

ISSN=2296-2360

ABSTRACT=The efficacy of dupilumab in pediatric patients with hyper-IgE (HIGE) syndrome is not known. Here we present the case of a child with HIGE syndrome in whom dupilumab treatment led to remarkable control of his eczema and recurrent skin infections. We also review the use of dupilumab in other patients with HIGE syndrome. Our case supports the notion that dupilumab may have a seminal application in treating the severe atopic symptoms that are seen in HIGE syndrome.