AUTHOR=Joshi Tejas P. , Anvari Sara , Gupta Meera R. , Davis Carla M. , Hajjar Joud TITLE=Case Report: Dupilumab Successfully Controls Severe Eczema in a Child With Elevated IgE Levels and Recurrent Skin Infections JOURNAL=Frontiers in Pediatrics VOLUME=Volume 9 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.646997 DOI=10.3389/fped.2021.646997 ISSN=2296-2360 ABSTRACT=The efficacy of dupilumab in pediatric patients with hyper-IgE (HIGE) syndrome is not known. Here we present the case of a child with HIGE syndrome in whom dupilumab treatment led to remarkable control of his eczema and recurrent skin infections. We also review the use of dupilumab in other patients with HIGE syndrome. Our case supports the notion that dupilumab may have a seminal application in treating the severe atopic symptoms that are seen in HIGE syndrome.