AUTHOR=Bottari Gabriella , Confalone Valerio , Cotugno Nicola , Guzzo Isabella , Perdichizzi Salvatore , Manno Emma C. , Stoppa Francesca , Cecchetti Corrado 

TITLE=Efficacy of CytoSorb in a Pediatric Case of Severe Multisystem Infammatory Syndrome (MIS-C): A Clinical Case Report

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 9 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2021.676298

DOI=10.3389/fped.2021.676298

ISSN=2296-2360

ABSTRACT=Background. Multisystem inflammatory syndrome in children (MIS-C) has emerged during the COVID-19 pandemic as a new SARS-CoV-2-related entity, potentially responsible for a life-threatening clinical condition associated with myocardial dysfunction and refractory shock. 
Case. We describe for the first time in a 14 year old girl with severe MIS-C the potential benefit of an adjuvant therapy based on Cytosorb hemoperfusion and Continuous Renal Replacement Therapy with immune-modulatory drugs. 
Conclusions. We show in our case that from the start of extracorporeal blood purification, there was a rapid and progressive restoration in cardiac function and hemodynamic parameters in association with a reduction in the most important inflammatory biomarkers (Interleukin 6, Interleukin 10, C-reactive protein, Ferritin, D-dimers).  Additionally, for the first time we were able to show with the analysis of the sublingual microcirculation, a delayed improvement in most of the important microcirculation parameters in this clinical case of MIS-C.