AUTHOR=Delefortrie T. , Ferdynus C. , Paye-Jaouen A. , Michel J. L. , Dobremez E. , Peycelon M. , El Ghoneimi A. , Harper L. 

TITLE=Evaluating the impact of pop-off mechanisms in boys with posterior urethral valves

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.1014422

DOI=10.3389/fped.2022.1014422

ISSN=2296-2360

ABSTRACT=Introduction
There have been several studies on the effect of pop-off mechanisms in boys with posterior ure-thral valves, but results are contradictory. We aimed to assess the effect of pop-off mechanisms on renal function in a large cohort of patients. 
Patients and method
Boys with PUV with and without pop-off mechanisms (urinoma, VURD or giant bladder diverticula) were divided into three severity groups for renal function according to their nadir creatinine (low-risk NC < 35 μmol/L, intermediate-risk NC between 35 and 75 μmol/L, and high-risk NC > 75 μmol/L). We compared children with and children without pop-off mechanisms for mean renal function as well as patient distribution within each severity group. 
Results 
We included 137 boys of which 39 had a pop-off mechanism. Patients had complete data for at least  2 years follow-up. Though there was no significant statistical difference in mean renal func-tion between the pop-off and non-pop-off group, patient distribution within each severity group varied according to whether patients had a pop-off mechanism or not. 
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