AUTHOR=Lv Jingjing , Zhang Jianwei , Zhang Kan , Zheng Jijian 

TITLE=Predictive value of EEG-derived pain threshold index for acute postoperative pain in children

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.1052532

DOI=10.3389/fped.2022.1052532

ISSN=2296-2360

ABSTRACT=EEG-derived Pain Threshold Index (PTI) has been developed as a novel pain recognition indicator and has been proved to be useful in prediction of acute postoperative pain in adults. Evidence of its usability in children is limited. The aim of this study was to investigate the prediction value of this novel pain indicator PTI for acute postoperative pain in children. A total of 80 patients undergoing laparoscopic surgery under general anesthesia were enrolled. Data of blood pressure (BP), heart rate (HR), surgical pleth index (SPI), PTI and EEG-derived sedative index-wavelet index (WLI) were recorded at the end of the surgery. The postoperative pain scores (FLACC) were obtained in the emergence room five minutes after the children wake up. Receiver-operating characteristic (ROC) curve was performed to analyze the predictive value of PTI, SPI, HR and MAP. The consistency between SPI and PTI was also evaluated. Results showed that the areas under curves (AUCs)[ 95%CI] of PTI and SPI were 0.796 [95%CI: 0.694-0.895] and 0.753[95%CI: 0.632-0.874] with the best cut-off value of 58 and 45 to discriminate between mild and moderate to severe pain. This study suggested that PTI obtained at the end of the surgery could predict acute postoperative pain in children with an acceptable accuracy. It will help with early recognition and treatment of postoperative pain, thus reducing the pain of children. In addition, PTI had a good consistency with SPI in predicting acute postoperative pain in children.