AUTHOR=Deng Zhengrong , Qin Jiangwei , Sun Huanbin , Xv Furong , Ma Yimei TITLE=Effectiveness of Impregnated Central Venous Catheters on Catheter-Related Bloodstream Infection in Pediatrics JOURNAL=Frontiers in Pediatrics VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.795019 DOI=10.3389/fped.2022.795019 ISSN=2296-2360 ABSTRACT=Background: The efficacy and safety of impregnated central venous catheters (CVCs) in pediatrics remain controversial. The purpose of this study was to evaluate the efficacy of impregnations for the prevention of catheter-related bloodstream infection (CRBSI). Methods: We searched the following 5 electronic databases: Medline, PubMed, Cochrane, Embase and the Web of Science for randomized controlled trials (RCTs) up to March 2021. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated using a fixed-effects model. Assessment of publication biases was evaluated by Egger’s test. Heterogeneity between studies was assessed based on the chi-square test and I2 statistics, and sensitivity analysis and subgroup analysis were also performed. Results: A total of 6 RCTs with 3,091 patients were included. Impregnated CVCs provided significant benefits in reducing the risk of catheter-related bloodstream infection (CRBSI) (RR=0.41, 95% CI 0.26 to 0.66) in pediatric patients, especially in the pediatric group. No publication bias was observed in the Egger test for the risk of CRBSI. Drug type is a source of heterogeneity. Conclusion: Antimicrobial impregnated CVCs are beneficial to prevent CVC-related complications in pediatrics.