AUTHOR=McCulloch Mignon I. , Adabayeri Victoria M. , Goka Selasie , Khumalo Tholang S. , Lala Nilesh , Leahy Shannon , Ngubane-Mwandla Nokukhanya , Nourse Peter J. , Nyann Beatrice I. , Petersen Karen L. , Levy Cecil S. TITLE=Perspectives: Neonatal acute kidney injury (AKI) in low and middle income countries (LMIC) JOURNAL=Frontiers in Pediatrics VOLUME=Volume 10 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.870497 DOI=10.3389/fped.2022.870497 ISSN=2296-2360 ABSTRACT=Neonatal AKI remains a challenge in Low and Middle Income Countries(LMIC). In this perspective we address issues of diagnosis and risk factors particular to less well resourced regions. The conservative management pre-kidney replacement therapy(pre-KRT) is prioritised and challenges of KRT are described. Special emphasis is placed on ethical and palliation principles.