AUTHOR=Zhu Yiming , Chen Xiaohui , Zhu Jingai , Jiang Chengyao , Yu Zhangbin , Su Ailing 

TITLE=Effect of First Mother's Own Milk Feeding Time on the Risk of Moderate and Severe Bronchopulmonary Dysplasia in Infants With Very Low Birth Weight

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.887028

DOI=10.3389/fped.2022.887028

ISSN=2296-2360

ABSTRACT=Objective: To explore the effect of mother’s own milk(MOM) feeding time on the risk of moderate and severe bronchopulmonary dysplasia (BPD) in very low birth weight infants (VLBW).  
Methods: Clinical data from 630 VLBW infants were retrospectively analyzed. Participants were divided into early mother’s own milk(EMOM) feeding group (first mother’s own milk feeding time ≤72 h after birth, n = 397) and late mother’s own milk(LMOM) feeding group (first mother’s own milk feeding time >72 h after birth, n = 233). Differences in the incidence of moderate and severe BPD among the two groups were analyzed using the chi-square test. Effect of MOM feeding time on the incidence of moderate and severe BPD were evaluated using univariate and multivariate logistic regression analysis. 
Results: The incidence of moderate and severe BPD in EMOM feeding group and LMOM feeding group were 13.9% (55/397) and 21.0% (49/233), respectively (P = 0.019). Variate logistic regression analysis showed that the LMOM feeding group had an increased risk of moderate and severe BPD compared with the EMOM feeding group (OR = 1.656, 95% CI:1.083–2.532). The results of multivariate logistic regression analysis showed that the LMOM feeding group had an increased risk of moderate and severe BPD compared with the EMOM feeding group (OR = 1.894, 95% CI:1.127–3.185).  
Conclusion: The first time of MOM feeding within 72 h after birth and the persistence of mother’s own milk feeding during hospitalization can reduce the incidence of moderate and severe BPD in VLBW infants.