AUTHOR=Dong Xiangjun , Luo Shuyue , Hu Dongjie , Cao Ruixue , Wang Qunxian , Meng Zijun , Feng Zijuan , Zhou Weihui , Song Weihong 

TITLE=Gallic acid inhibits neuroinflammation and reduces neonatal hypoxic-ischemic brain damages

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.973256

DOI=10.3389/fped.2022.973256

ISSN=2296-2360

ABSTRACT=Neuroinflammation is a leading cause of secondary neuronal injury in neonatal hypoxic ischemic encephalopathy (HIE). Regulation of neuroinflammation may be beneficial for HIE and its secondary complications. Gallic acid (GA) has been shown to have an anti-inflammatory and antioxidant effect. In this report we found that oxygen-glucose deprivation and /re-oxygenation (OGD/R)-induced cell death, the generation of excessive reactive oxygen species (ROS) and inflammatory cytokines by microglia was inhibited by GA treatment. Furthermore, GA treatment reduced neuroinflammation and neuron loss, as well as alleviate motor and cognitive impairments in rats with hypoxic-ischemic brain damage (HIBD). Together, our study reveals that GA is an effective regulator of neuroinflammation and has a pharmaceutical potential for HIE therapy.