AUTHOR=Mauro Angela , Casini Francesca , Talenti Antonella , Di Mari Clelia , Benincaso Anna Rita , Di Nardo Giovanni , Bernardo Luca TITLE=Celiac crisis as the life-threatening onset of celiac disease in children: a case report JOURNAL=Frontiers in Pediatrics VOLUME=Volume 11 - 2023 YEAR=2023 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2023.1163765 DOI=10.3389/fped.2023.1163765 ISSN=2296-2360 ABSTRACT=Celiac disease (CD) is an immune mediated enteropathy, caused by permanent sensitivity to gluten in genetically susceptible individuals. In rare cases, CD may occur with a severe potential life-threatening manifestation, known as celiac crisis (CC). This may be a consequence of a delayed diagnosis and expose patients to possible fatal complications. We report the case of a 22-month-old child, admitted to our hospital for a CC characterised by weight loss, vomit and diarrhoea associated with a malnutrition state. Early identification of symptoms of CC is essential to provide a prompt diagnosis and management.