AUTHOR=Di Meglio Lavinia , Sica Giordana , Toscano Paolo , Orlandi Giuliana , Manzo Luigi , Mazzarelli Laura Letizia , Sica Carmine , Di Meglio Aniello 

TITLE=A systematic review of prenatally diagnosed vein of Galen malformations: prenatal predictive markers and management from fetal life to childhood

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1401468

DOI=10.3389/fped.2024.1401468

ISSN=2296-2360

ABSTRACT=Introduction:  Vein of Galen malformations (VGMs)account for less than 1% of all intracranial vascular malformations. However, in the fetal and pediatric populations, they represent the most common vascular malformation of the brain. An optimal knowledge of the prenatal and postnatal clinical features is mandatory for effective management.
Methods: Articles published between 1st January 2003 and 31st January 2024, reported in PUBMED and EMBASE, were evaluated for a systematic review analyzing prenatal and postnatal features and management of fetal Galean VGMs.
Results: Thirty-one papers reporting information on 51 prenatally-diagnosed VGM were included. The most common prenatal features were: fetal hydrocephalus (39%) and cardiomegaly (56%). Post-natal data of 43 VGM cases are described. The overall mortality was 58,14%. 77,78 % of the survivors had a normal development.
Conclusions: A close follow-up and a multidisciplinary approach is mandatory to manage this condition. Our study aimed to provide a guide to gynecologists, neonatologists, cardiologists, and neuroradiologists.