AUTHOR=Kaffai Stefanie , Angelova-Toshkin Daniela , Weins Andreas B. , Ickinger Sonja , Steinke-Lange Verena , Vollert Kurt , Frühwald Michael C. , Kuhlen Michaela 

TITLE=Cancer predisposing syndromes in childhood and adolescence pose several challenges necessitating interdisciplinary care in dedicated programs

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1410061

DOI=10.3389/fped.2024.1410061

ISSN=2296-2360

ABSTRACT=Introduction: Genetic disposition is a major etiologic factor in childhood cancer. More than 100 cancer predisposing syndromes (CPS) are known. Surveillance protocols seek to mitigate morbidity and mortality. To implement recommendations in patient care and to ascertain that the constant gain of knowledge forces its way into practice specific pediatric CPS programs were established.Patients and methods: We retrospectively analyzed data on children, adolescents, and young adults referred to our pediatric CPS program between