AUTHOR=De Rose Domenico Umberto , Maddaloni Chiara , Salvatori Guglielmo , Campi Francesca , Gatto Antonio , Martini Ludovica , Savarese Immacolata , Bersani Iliana , Ubertini Graziamaria , Serrao Francesca , Costa Simonetta , Braguglia Annabella , Gallini Francesca , Vento Giovanni , Dotta Andrea 

TITLE=Case Report: Hypercalcemia, subcutaneous fat necrosis and nephrocalcinosis in neonates who undergo therapeutic hypothermia: a not so rare association, with different onset time

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 12 - 2024

YEAR=2025

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1477378

DOI=10.3389/fped.2024.1477378

ISSN=2296-2360

ABSTRACT=Subcutaneous fat necrosis (SCFN) in newborns is an uncommon and self-limiting non-infectious panniculitis. It can occur in the first weeks of life in full-term newborns with hypoxic-ischemic encephalopathy who underwent therapeutic hypothermia. Hypercalcemia may develop and has been implicated as the cause of several complications as nephrocalcinosis. Hypercalcemia has been previously reported to appear only after resolution of skin lesions. Herein, we report how hypercalcemia can be evident already at diagnosis of subcutaneous fat necrosis after therapeutic hypothermia and can be associated with an early onset developing nephrocalcinosis. We compare two cases of these uncommon findings and review the recent literature.