AUTHOR=Trah Julian , Deindl Philipp , Luister Alexandra , Langebrake Claudia , Singer Dominique , Ebenebe Chinedu Ulrich 

TITLE=Factors associated with elevated gentamicin trough levels in neonates: a retrospective analysis of dosing and clinical parameters

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1510838

DOI=10.3389/fped.2025.1510838

ISSN=2296-2360

ABSTRACT=ObjectiveInvestigate determinants of elevated gentamicin trough levels in neonates.MethodsThis single-center retrospective analysis used a multivariate linear regression model to explore the relationship between gentamicin trough concentrations and factors such as creatinine levels, dosage, day of life, sex, CRP levels, and dosing interval in neonates.ResultsIn 215 neonates, including 68 (31.6%) premature neonates with a postmenstrual age of ≤35 weeks, shorter dosing intervals, higher creatinine levels, and increased dosage were linked to higher gentamicin trough levels. Elevated CRP levels corresponded with lower trough levels.ConclusionThis study highlights the critical role of dosing frequency, kidney function, and inflammatory status in influencing gentamicin trough levels in neonates. However, all gentamicin trough levels were within the 2 µg/ml threshold.