AUTHOR=Deleon Alex , Murala Anish , Decker Isabelle , Rajasekaran Karthik , Moreira Alvaro 

TITLE=Machine learning-based prediction of mortality in pediatric trauma patients

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1522845

DOI=10.3389/fped.2025.1522845

ISSN=2296-2360

ABSTRACT=BackgroundThis study aimed to develop a predictive model for mortality outcomes among pediatric trauma patients using machine learning (ML) algorithms.MethodsWe extracted data on a cohort of pediatric trauma patients (18 years and younger) from the National Trauma Data Bank (NTDB). The main aim was to identify clinical and physiologic variables that could serve as predictors for pediatric trauma mortality. Data was split into a development cohort (70%) to build four ML models and then tested in a validation cohort (30%). The area under the receiver operating characteristic curve (AUC) was used to assess each model's performance.ResultsIn 510,381 children, the gross mortality rate was 1.6% (n = 8,250). Most subjects were male (67%, n = 342,571) and white (62%, n = 315,178). The AUCs of the four models ranged from 92.7 to 97.7 with XGBoost demonstrating the highest AUC. XGBoost demonstrated the highest accuracy of 97.7%.ConclusionMachine learning algorithms can be effectively utilized to build an accurate pediatric mortality prediction model that leverages variables easily obtained upon trauma admission.