AUTHOR=Zhang Xiumin , Yang Juan , Guo Cuicui , Wang Jingcai 

TITLE=Low molecular weight heparin calcium sequential rivaroxaban for the treatment of cerebral venous sinus thrombosis and cortical venous infarction in children with nephrotic syndrome: case report

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1566114

DOI=10.3389/fped.2025.1566114

ISSN=2296-2360

ABSTRACT=Cerebral venous sinus thrombosis (CVST), though exceedingly rare, represents a serious complication in pediatric patients with nephrotic syndrome (NS). We describe an 11-year-old male with steroid-resistant nephrotic syndrome (SRNS) maintained on prednisone/tacrolimus therapy who subsequently developed CVST. The patient manifested respiratory/gastrointestinal symptoms (cough, diarrhea) followed by neurologic deterioration featuring headache, seizures, and altered consciousness. Magnetic resonance imaging (MRI) and magnetic resonance venography (MRV) confirmed transverse sinus thrombosis with cortical venous infarction. A 5-day course of low-molecular-weight heparin (LMWH) followed by rivaroxaban achieved safe thrombus resolution, supporting this anticoagulation protocol in pediatric NS.