AUTHOR=Di Majo Benedetta Elena , Peccatori Nicolò , Inzoli Alessandra , Degrate Luca , Jaconi Marta , Ratti Michele , Casiraghi Alessandra , Ferrari Giulia Maria , Sala Debora , Biondi Andrea , Passoni Paolo , Corti Paola 

TITLE=Case Report: Post-splenectomy bulky pelvic splenosis in an adolescent with hereditary spherocytosis

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1581533

DOI=10.3389/fped.2025.1581533

ISSN=2296-2360

ABSTRACT=Splenectomy is a well-established therapeutic approach for pediatric hematologic disorders, especially in the case of hereditary spherocytosis (HS). In addition to the commonly acknowledged short- and long-term infectious and thrombotic complications, also splenosis represents a rare but noteworthy complication of splenectomy. Splenosis is characterized by the auto-transplantation and growth of splenic tissue in ectopic locations, following trauma or splenectomy. This condition can mimic malignancies, posing diagnostic challenges. We report the case of a 16-year-old girl with HS who presented with fever, abdominal pain, and a history of laparoscopic splenectomy ten years early. Imaging revealed a vascularized pelvic mass, initially suspected to be malignant. Diagnostic laparoscopy and histopathological analysis confirmed the mass as pelvic splenosis. The patient was asymptomatic, prompting a conservative management approach with regular follow-up. This case highlights the importance of considering splenosis in differential diagnoses for pelvic masses in patients with prior splenectomy, to ensure appropriate management and avoid unnecessary interventions.