AUTHOR=Wu Ri Ni Letu , Nong Yimin , Wang Jinben , Liang Xiujian , Zhang Baoxin , Lin Zhenying TITLE=Case Report: Giant sacrococcygeal teratoma in neonates—a report of three cases JOURNAL=Frontiers in Pediatrics VOLUME=Volume 13 - 2025 YEAR=2025 URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1600920 DOI=10.3389/fped.2025.1600920 ISSN=2296-2360 ABSTRACT=Although most cases of neonatal sacrococcygeal teratoma are benign, some can grow into very large lesions, potentially causing high-output heart failure, massive bleeding, disseminated intravascular coagulation, and even fatal outcomes. We report three cases of giant sacrococcygeal teratomas, detailing their diagnostic and therapeutic management. We emphasize that clinicians should be prepared with comprehensive contingency plans and that interdisciplinary collaboration is essential to enhance patient survival rates and minimize potential complications.