AUTHOR=Nahari Majed , Alaboud Mohammed , Mohinuddin Syed , Faden Maheer , Balhareth Yasser , Alsaleem Noura 

TITLE=Successful sequential therapy for Stenotrophomonas maltophilia infection in a preterm neonate: a case report

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 13 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2025.1619075

DOI=10.3389/fped.2025.1619075

ISSN=2296-2360

ABSTRACT=BackgroundA multidrug-resistant pathogen increasingly seen in newborn intensive care units, stenotrophomonas maltophilia presents treatment difficulties for preterm babies.Case presentationA 28-week preterm neonate developed S. maltophilia sepsis following prolonged mechanical ventilation. Initial therapy with trimethoprim- sulfamethoxazole (TMP-SMX) was ineffective, prompting a switch to levofloxacin, which led to clinical recovery and infection clearance.ConclusionThis case highlights the need for tailored antimicrobial strategies in neonatal S. maltophilia infections. Sequential therapy with TMP-SMX and levofloxacin was effective, supporting the judicious use of fluoroquinolones in resistant cases.